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NDB ID: 6FQM    PDB ID: 6FQM 


Title:

3.06A COMPLEX OF S.AUREUS GYRASE WITH IMIDAZOPYRAZINONE T1 AND DNA

Molecular Description:

DNA gyrase subunit B
DNA gyrase subunit A/DNA Complex

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Germe, T., Voros, J., Jeannot, F., Taillier, T., Stavenger, R.A., Bacque, E., Maxwell, A., Bax, B.D.
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. 
Nucleic Acids Res., 46, pp. 4114 - 4128, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 88.34   b = 171.71   c = 124.87 (Ångstroms)

α = 90.0   β = 102.86   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.19678 for 64115 reflections in the resolution range 59.9 to 3.06 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)