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NDB ID: 6FWK    PDB ID: 6FWK 


Title:

THE CRYSTAL STRUCTURE OF POL2CORE-M644G IN COMPLEX WITH DNA AND AN INCOMING NUCLEOTIDE

Molecular Description:

DNA polymerase epsilon catalytic subunit A/DNA Complex

Deposited:

2018-03-06

Released:

2019-01-30

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Parkash, V., Kulkarni, Y., Ter Beek, J., Shcherbakova, P.V., Kamerlin, S.C.L., Johansson, E.
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. 
Nat Commun, 10, pp. 373 - 373, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 2 1

Cell Constants:

a = 153.961   b = 70.342   c = 158.965 (Ångstroms)

α = 90.0   β = 112.82   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2249 for 107685 reflections in the resolution range 19.988 to 2.503 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)