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NDB ID: 6HAK    PDB ID: 6HAK 


Title:

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH A DOUBLE STRANDED RNA REPRESENTS THE RT TRANSCRIPTION INITIATION COMPLEX PRIOR TO NUCLEOTIDE INCORPORATION

Molecular Description:

Gag-Pol polyprotein/RNA Complex

Deposited:

2018-08-07

Released:

2019-04-03

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.E., DeStefano, J.J., Arnold, E.
Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation. 
Proc.Natl.Acad.Sci.USA, 116, pp. 7308 - 7313, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 175.24   b = 175.24   c = 225.8 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.296 for 31441 reflections in the resolution range 87.62 to 3.95 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)