NDB ID: 6HMO    PDB ID: 6HMO     NAKB: 6HMO 

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Title:

SOLUTION STRUCTURE OF THE RNA DUPLEX FORMED BY THE 5'-END OF U1SNRNA AND THE 5'-SPLICE SITE OF SMN2 EXON7 IN COMPLEX WITH THE SMN-C5 SPLICING MODIFIER

Molecular Description:

RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3')
RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')

Deposited:

2018-09-12

Released:

2019-08-14

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Campagne, S., Boigner, S., Rudisser, S., Moursy, A., Gillioz, L., Knorlein, A., Hall, J., Ratni, H., Clery, A., Allain, F.H.
Structural basis of a small molecule targeting RNA for a specific splicing correction. 
Nat.Chem.Biol., 15, pp. 1191 - 1198, 2019.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 20 Structures

Sample Details:

10 mM deuterated MES, 50 mM unlabelled sodium chloride, 6 % deuterated glycerol, 100% D2O 100% D2O

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Biological Assembly coordinates (pdb format) 

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Coordinates (cif format, Unix compressed(.gz))

NMR Restraints (cif format, Unix compressed(.gz))

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