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NDB ID: 6HYU    PDB ID: 6HYU 


Title:

CRYSTAL STRUCTURE OF DHX8 HELICASE BOUND TO SINGLE STRANDED POLY-ADENINE RNA

Molecular Description:

ATP-dependent RNA helicase DHX8/RNA Complex

Deposited:

2018-10-22

Released:

2019-08-28

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Felisberto-Rodrigues, C., Thomas, J.C., McAndrew, C., Le Bihan, Y.V., Burke, R., Workman, P., van Montfort, R.L.M.
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. 
Biochem.J., 476, pp. 2521 - 2543, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 2 21

Cell Constants:

a = 66.104   b = 138.601   c = 169.143 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the BUSTER program. The R value is 0.229 for 25904 reflections in the resolution range 48.75 to 3.22 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)