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NDB ID: 6I8A    PDB ID: 6I8A 


Title:

THE CRYSTAL STRUCTURE OF THE POL2 CATALYTIC DOMAIN OF DNA POLYMERASE EPSILON CARRYING A P301R SUBSTITUTION.

Molecular Description:

DNA polymerase epsilon catalytic subunit A/DNA Complex

Deposited:

2018-11-19

Released:

2019-01-30

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Parkash, V., Kulkarni, Y., Ter Beek, J., Shcherbakova, P.V., Kamerlin, S.C.L., Johansson, E.
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. 
Nat Commun, 10, pp. 373 - 373, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 2 1

Cell Constants:

a = 154.466   b = 70.257   c = 159.335 (Ångstroms)

α = 90.0   β = 112.85   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2315 for 90534 reflections in the resolution range 19.957 to 2.652 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)