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NDB ID: 6IKA    PDB ID: 6IKA 


Title:

HIV-1 REVERSE TRANSCRIPTASE WITH Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:ENTECAVIR-TRIPHOSPHATE TERNARY COMPLEX

Molecular Description:

HIV-1 RT p66 subunit/HIV-1 RT p51 subunit/DNA Complex

Deposited:

2018-10-15

Released:

2019-01-30

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Yasutake, Y., Hattori, S.I., Tamura, N., Matsuda, K., Kohgo, S., Maeda, K., Mitsuya, H.
Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. 
Biochem. Biophys. Res. Commun., 509, pp. 943 - 948, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 285.405   b = 285.405   c = 96.346 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1881 for 89774 reflections in the resolution range 48.869 to 2.598 Ångstroms with Fobs >  1.98 sigma(Fobs) and with I >  0.0 sigma(I)