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NDB ID: 6JJ0    PDB ID: 6JJ0 


Title:

NMR STRUCTURE OF THE 1:1 COMPLEX OF A CARBAZOLE DERIVATIVE BMVC BOUND TO C-MYC G-QUADRUPLEX

Molecular Description:

DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3')

Deposited:

2019-02-24

Released:

2019-10-30

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Liu, W., Lin, C., Wu, G., Chang, T.C., Yang, D.
Solution structures of the c-MYC Promoter G-quadruplex bound to a carbazole derivative: Insights into small molecule conformational switch for optimal G4-binding
Nucleic Acids Res., , pp. - , 2019.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 20 Structures

Sample Details:

2.0 mM NA- DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), 1.0 mM NA- BMVC, 25 mM NA- potassium phosphate, 70 mM NA- potassium chloride, 90% H2O/10% D2O 90% H2O/10% D2O