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NDB ID: 6LTU    PDB ID: 6LTU 


Title:

CRYSTAL STRUCTURE OF CAS12I2 TERNARY COMPLEX WITH DOUBLE MG2+ BOUND IN CATALYTIC POCKET

Molecular Description:

Cas12i2/RNA/DNA Complex

Deposited:

2020-01-23

Released:

2020-10-28

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 4 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Huang, X., Sun, W., Cheng, Z., Chen, M., Li, X., Wang, J., Sheng, G., Gong, W., Wang, Y.
Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. 
Nat Commun, 11, pp. 5241 - 5241, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 94.329   b = 123.575   c = 281.218 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2033 for 51108 reflections in the resolution range 46.87 to 2.57 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)