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NDB ID: 6M4T    PDB ID: 6M4T 


Title:

U SHAPED HEAD TO HEAD FOUR-WAY JUNCTION IN D(TTCTGCTGCTGAA) SEQUENCE

Molecular Description:

DNA (5'-D(P*(UD)P*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3')

Deposited:

2020-03-09

Released:

2020-07-15

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Chien, C.M., Wu, P.C., Satange, R., Chang, C.C., Lai, Z.L., Hagler, L.D., Zimmerman, S.C., Hou, M.H.
Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA. 
J.Am.Chem.Soc., 142, pp. 11165 - 11172, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 57.204   b = 62.631   c = 29.743 (Ångstroms)

α = 90.0   β = 121.29   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1675 for 13071 reflections in the resolution range 19.734 to 1.55 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)