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NDB ID: 6M5J    PDB ID: 6M5J 


Title:

U SHAPED HEAD TO HEAD FOUR-WAY JUNCTION IN D(TTCTGCTGCTGAA/TTCTGCAGCTGAA) SEQUENCE

Molecular Description:

DNA (5'-D(P*TP*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3')
DNA (5'-D(P*TP*TP*CP*TP*GP*CP*AP*GP*CP*TP*GP*AP*A)-3')

Deposited:

2020-03-11

Released:

2020-07-15

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Chien, C.M., Wu, P.C., Satange, R., Chang, C.C., Lai, Z.L., Hagler, L.D., Zimmerman, S.C., Hou, M.H.
Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA. 
J.Am.Chem.Soc., 142, pp. 11165 - 11172, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 57.63   b = 62.086   c = 30.747 (Ångstroms)

α = 90.0   β = 121.84   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1876 for 10816 reflections in the resolution range 19.221 to 1.65 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)