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NDB ID: 6M7U    PDB ID: 6M7U 


Title:

HUMAN DNA POLYMERASE ETA IN A NON-PRODUCTIVE TERNARY COMPLEX WITH MG2+ AND DTMPNPP OPPOSITING CDA

Molecular Description:

DNA polymerase eta/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Weng, P.J., Gao, Y., Gregory, M.T., Wang, P., Wang, Y., Yang, W.
Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. 
Proc. Natl. Acad. Sci. U.S.A., 115, pp. 10660 - 10665, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 63.31   b = 80.47   c = 142.07 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2563 for 9840 reflections in the resolution range 29.458 to 3.4 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)