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NDB ID: 6MCF    PDB ID: 6MCF 


Title:

SOLUTION STRUCTURE OF 7SK STEM-LOOP 1 WITH HIV-1 TAT RNA BINDING DOMAIN

Molecular Description:

Protein Tat/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Pham, V.V., Salguero, C., Khan, S.N., Meagher, J.L., Brown, W.C., Humbert, N., de Rocquigny, H., Smith, J.L., D'Souza, V.M.
HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry. 
Nat Commun, 9, pp. 4266 - 4266, 2018.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Number of Models:

Number of Models: 10 Structures

Sample Details:

0.5 mM 7SK Stem-loop 1 RNA, 0.5 mM [U-13C; U-15N] HIV-1 Tat RNA Binding Domain selectively labeled with the following schema: 1) R49, K50, R57, A58 2) K51, R52, Q54, R55 3) R53, Q54, R56, 90% H2O/10% D2O 90% H2O/10% D2O