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NDB ID: 6MR7    PDB ID: 6MR7 


Title:

DNA POLYMERASE BETA SUBSTRATE COMPLEX WITH TEMPLATING ADENINE AND INCOMING FAPY-DGTP ANALOG

Molecular Description:

DNA polymerase beta/DNA Complex

Deposited:

2018-10-11

Released:

2019-01-30

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Smith, M.R., Shock, D.D., Beard, W.A., Greenberg, M.M., Freudenthal, B.D., Wilson, S.H.
A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. 
Nucleic Acids Res., 47, pp. 3197 - 3207, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 55.032   b = 79.825   c = 55.518 (Ångstroms)

α = 90.0   β = 110.6   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1909 for 43797 reflections in the resolution range 24.711 to 2.144 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)