A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 30-Nov-2022 number of released structures: 12490
Search for released structures

NDB ID: 6N4O    PDB ID: 6N4O     NAKB(beta): 6N4O 


Title:

HUMAN ARGONAUTE2-MIR-122 BOUND TO A SEED AND SUPPLEMENTARY PAIRED TARGET

Molecular Description:

Protein argonaute-2/RNA Complex

Deposited:

2018-11-19

Released:

2019-05-08

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Sheu-Gruttadauria, J., Xiao, Y., Gebert, L.F., MacRae, I.J.
Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. 
Embo J., 38, pp. e101153 - e101153, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 66.132   b = 66.328   c = 247.677 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2099 for 24133 reflections in the resolution range 39.0 to 2.899 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)