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NDB ID: 6N65    PDB ID: 6N65 


Title:

KRAS G-QUADRUPLEX G16T MUTANT.

Molecular Description:

KRAS G-quadruplex G16T mutant

Deposited:

2018-11-25

Released:

2020-04-15

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Ou, A., Schmidberger, J.W., Wilson, K.A., W Evans, C., Hargreaves, J.A., Grigg, M., O'Mara, M.L., Iyer, K.S., Bond, C.S., Smith, N.M.
High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition. 
Nucleic Acids Res., , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 33.693   b = 30.127   c = 52.97 (Ångstroms)

α = 90.0   β = 94.51   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2115 for 13707 reflections in the resolution range 29.409 to 1.6 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)