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NDB ID: 6NIT    PDB ID: 6NIT 


Title:

HUMAN ARGONAUTE2-MIR-122 BOUND TO A TARGET RNA WITH FOUR CENTRAL MISMATCHES (BU4)

Molecular Description:

Protein argonaute-2/RNA Complex

Deposited:

2018-12-31

Released:

2019-08-07

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Sheu-Gruttadauria, J., Pawlica, P., Klum, S.M., Wang, S., Yario, T.A., Schirle Oakdale, N.T., Steitz, J.A., MacRae, I.J.
Structural Basis for Target-Directed MicroRNA Degradation. 
Mol.Cell, , pp. - , 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 106.712   b = 137.086   c = 154.064 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2453 for 23073 reflections in the resolution range 39.301 to 3.8 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)