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NDB ID: 6O9E    PDB ID: 6O9E 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA AND INDOPY-1

Molecular Description:

Reverse transcriptase p66
Reverse transcriptase p51/DNA Complex

Deposited:

2019-03-13

Released:

2019-10-23

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Ruiz, F.X., Hoang, A., Das, K., Arnold, E.
Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. 
J.Med.Chem., , pp. - , 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.762   b = 127.663   c = 131.61 (Ångstroms)

α = 90.0   β = 101.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2037 for 113316 reflections in the resolution range 50.0 to 2.4 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)