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NDB ID: 6OF1    PDB ID: 6OF1 


Title:

CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH DIRITHROMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.80A RESOLUTION

Molecular Description:

70S ribosome

Deposited:

2019-03-28

Released:

2019-04-17

Nucleic Acid Sequence:

Click to show/hide 6 nucleic acid sequences

Protein Sequence:

Click to show/hide 49 protein sequences

Primary Citation:

Khabibullina, N.F., Tereshchenkov, A.G., Komarova, E.S., Syroegin, E.A., Shiriaev, D.I., Paleskava, A., Kartsev, V.G., Bogdanov, A.A., Konevega, A.L., Dontsova, O.A., Sergiev, P.V., Osterman, I.A., Polikanov, Y.S.
Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides. 
Antimicrob.Agents Chemother., 63, pp. - , 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 208.15   b = 446.4   c = 615.53 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.217 for 1385414 reflections in the resolution range 253.382 to 2.8 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)