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NDB ID: 6P1I    PDB ID: 6P1I 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH DSDNA AND DCTP

Molecular Description:

Reverse transcriptase/ribonuclease H
p51 RT/DNA Complex

Deposited:

2019-05-19

Released:

2019-07-24

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Bertoletti, N., Chan, A.H., Schinazi, R.F., Yin, Y.W., Anderson, K.S.
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. 
Protein Sci., 28, pp. 1664 - 1675, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 166.417   b = 169.504   c = 103.063 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1855 for 38466 reflections in the resolution range 28.927 to 2.74 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)