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NDB ID: 6P1N    PDB ID: 6P1N 


Title:

PRE-CATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE MU WITH 1-NT GAPPED SUBSTRATE CONTAINING TEMPLATE 8OG AND BOUND INCOMING DAMPNPP

Molecular Description:

DNA-directed DNA/RNA polymerase mu/DNA Complex

Deposited:

2019-05-20

Released:

2019-09-04

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kaminski, A.M., Chiruvella, K.K., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. 
Nucleic Acids Res., 47, pp. 9410 - 9422, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 59.926   b = 68.772   c = 110.609 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1661 for 60585 reflections in the resolution range 26.659 to 1.6 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)