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NDB ID: 6Q02    PDB ID: 6Q02 


Title:

POLYMERASE ETA-CATALYZED INSERTION OF THE MISMATCHED A OPPOSITE TEMPLATE CYTARABINE (ARAC) RESIDUE

Molecular Description:

DNA polymerase eta/DNA Complex

Deposited:

2019-08-01

Released:

2019-11-20

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Rechkoblit, O., Johnson, R.E., Buku, A., Prakash, L., Prakash, S., Aggarwal, A.K.
Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta. 
Sci Rep, 9, pp. 16400 - 16400, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 98.974   b = 98.974   c = 81.791 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1936 for 27041 reflections in the resolution range 85.72 to 2.09 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)