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NDB ID: 6S15    PDB ID: 6S15 


Title:

PYRIDINE DERIVATIVE OF THE NATURAL ALKALOID BERBERINE AS HUMAN TELOMERIC G-QUADRUPLEX BINDER

Molecular Description:

DNA TAGGGTTAGGGT

Deposited:

2019-06-18

Released:

2020-06-03

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Papi, F., Bazzicalupi, C., Ferraroni, M., Ciolli, G., Lombardi, P., Khan, A.Y., Kumar, G.S., Gratteri, P.
Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study. 
Acs Med.Chem.Lett., 11, pp. 645 - 650, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 41.25   b = 41.25   c = 68.6 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2684 for 6173 reflections in the resolution range 35.35 to 1.7 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)