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NDB ID: 6SNJ    PDB ID: 6SNJ 


Title:

SOLUTION STRUCTURE OF THE FUS/TLS RNA RECOGNITION MOTIF IN COMPLEX WITH U1 SNRNA STEM LOOP III

Molecular Description:

RNA-binding protein FUS/RNA Complex

Deposited:

2019-08-26

Released:

2020-10-28

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jutzi, D., Campagne, S., Schmidt, R., Reber, S., Mechtersheimer, J., Gypas, F., Schweingruber, C., Colombo, M., von Schroetter, C., Loughlin, F.E., Devoy, A., Hedlund, E., Zavolan, M., Allain, F.H., Ruepp, M.D.
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced Amyotrophic Lateral Sclerosis
Nat Commun, , pp. - , 2020.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 18 Structures

Sample Details:

1.2 mM [U-99% 13C; U-99% 15N] FUS/TLS RNA recognition motif (260-390), 1.5 mM SL3, 10 mM sodium phosphate, 50 mM sodium chloride, 2 mM DTT, 90% H2O/10% D2O 90% H2O/10% D2O