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NDB ID: 6U6B    PDB ID: 6U6B 


Title:

STRUCTURE OF HUMAN DNA POLYMERASE BETA MISINSERTING DAMPNPP OPPOSITE THE 5'G OF THE CISPLATIN PT-GG INTRASTRAND CROSSLINK WITH MANGANESE IN THE ACTIVE SITE

Molecular Description:

DNA polymerase beta/DNA Complex

Deposited:

2019-08-29

Released:

2020-09-09

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ouzon-Shubeita, H., Vilas, C.K., Lee, S.
Structures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 53.43   b = 78.216   c = 53.965 (Ångstroms)

α = 90.0   β = 110.57   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2244 for 7279 reflections in the resolution range 44.138 to 3.108 Ångstroms with Fobs >  0.14 sigma(Fobs) and with I >  0.0 sigma(I)