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NDB ID: 6U8D    PDB ID: 6U8D 


Title:

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS IRES JUNCTION IIIABC IN COMPLEX WITH FAB HCV2

Molecular Description:

Heavy chain of Fab HCV2
Light chain of Fab HCV2/RNA Complex

Deposited:

2019-09-04

Released:

2019-12-04

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A.
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. 
Acs Chem.Biol., 15, pp. 205 - 216, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 49.705   b = 161.223   c = 96.978 (Ångstroms)

α = 90.0   β = 102.66   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1746 for 67011 reflections in the resolution range 61.362 to 1.807 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)