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NDB ID: 6U8K    PDB ID: 6U8K 


Title:

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS IRES JUNCTION IIIABC IN COMPLEX WITH FAB HCV3

Molecular Description:

Heavy chain of Fab HCV3
Light chain of Fab HCV3/RNA Complex

Deposited:

2019-09-05

Released:

2019-12-04

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A.
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. 
Acs Chem.Biol., , pp. - , 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43

Cell Constants:

a = 173.289   b = 173.289   c = 140.49 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1871 for 106173 reflections in the resolution range 173.289 to 2.75 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)