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NDB ID: 6UJY    PDB ID: 6UJY 


Title:

HIV-1 WILD-TYPE REVERSE TRANSCRIPTASE-DNA COMPLEX WITH (-)-3TC-TP

Molecular Description:

Reverse transcriptase/RNaseH/DNA Complex

Deposited:

2019-10-03

Released:

2019-12-25

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Hung, M., Tokarsky, E.J., Lagpacan, L., Zhang, L., Suo, Z., Lansdon, E.B.
Elucidating molecular interactions ofL-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance. 
Commun Biol, 2, pp. 469 - 469, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 166.702   b = 169.479   c = 102.766 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.179954 for 41844 reflections in the resolution range 47.4573 to 2.59456 Ångstroms with Fobs >  1.33556 sigma(Fobs) and with I >  0.0 sigma(I)