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NDB ID: 6UOK    PDB ID: 6UOK 


Title:

Y271G DNA POLYMERASE BETA SUBSTRATE COMPLEX WITH TEMPLATING CYTOSINE AND INCOMING R8-OXO-GTP

Molecular Description:

DNA polymerase beta/DNA Complex

Deposited:

2019-10-15

Released:

2020-01-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Smith, M.R., Alnajjar, K.S., Hoitsma, N.M., Sweasy, J.B., Freudenthal, B.D.
Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta. 
J.Biol.Chem., 295, pp. 1613 - 1622, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.687   b = 79.957   c = 100.832 (Ångstroms)

α = 90.0   β = 97.642   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2285 for 42693 reflections in the resolution range 24.14 to 2.55 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)