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NDB ID: 6UPY    PDB ID: 6UPY 


Title:

RNA POLYMERASE II ELONGATION COMPLEX WITH 5-GUANIDINOHYDANTOIN LESION IN STATE 2E

Molecular Description:

DNA-directed RNA polymerase II subunit RPB1
DNA-directed RNA polymerase II subunit RPB2
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerases I
II
and III subunit RPABC1
DNA-directed RNA polymerases I
II
and III subunit RPABC2
DNA-directed RNA polymerases I
II
and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I
II
and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11
DNA-directed RNA polymerases I
II
and III subunit RPABC4/RNA/DNA Complex

Deposited:

2019-10-18

Released:

2020-06-10

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 10 protein sequences

Primary Citation:

Oh, J., Fleming, A.M., Xu, J., Chong, J., Burrows, C.J., Wang, D.
RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions. 
Proc.Natl.Acad.Sci.USA, 117, pp. 9338 - 9348, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 168.536   b = 223.125   c = 193.062 (Ångstroms)

α = 90.0   β = 100.92   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2283 for 95532 reflections in the resolution range 49.218 to 3.4 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)