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NDB ID: 6V0L    PDB ID: 6V0L 


Title:

PDGFR-B PROMOTER FORMS A G-VACANCY QUADRUPLEX THAT CAN BE COMPLEMENTED BY DGMP: MOLECULAR STRUCTURE AND RECOGNITION OF GUANINE DERIVATIVES AND METABOLITES

Molecular Description:

DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3')

Deposited:

2019-11-18

Released:

2020-03-11

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Wang, K.B., Dickerhoff, J., Wu, G., Yang, D.
PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs. 
J.Am.Chem.Soc., 142, pp. 5204 - 5211, 2020.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 10 Structures

Sample Details:

3600 uM 1H DNA (5'-D(*(DA5)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*(DA3)P*-3')(DGP), 90% H2O/10% D2O 90% H2O/10% D2O