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NDB ID: 6VA4    PDB ID: 6VA4 


Title:

SOLUTION STRUCTURE OF THE TAU PRE-MRNA EXON 10 SPLICING REGULATORY ELEMENT BOUND TO MIP

Molecular Description:

RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3')
RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3')

Deposited:

2019-12-16

Released:

2020-05-20

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Chen, J.L., Zhang, P., Abe, M., Aikawa, H., Zhang, L., Frank, A.J., Zembryski, T., Hubbs, C., Park, H., Withka, J., Steppan, C., Rogers, L., Cabral, S., Pettersson, M., Wager, T.T., Fountain, M.A., Rumbaugh, G., Childs-Disney, J.L., Disney, M.D.
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. 
J.Am.Chem.Soc., 142, pp. 8706 - 8727, 2020.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 20 Structures

Sample Details:

0.4 mM WT Tau RNA, 0.6 mM MIP, 10 mM KH2PO4/K2HPO4, 0.05 mM EDTA, 100% D2O 100% D2O