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NDB ID: 6VFF    PDB ID: 6VFF 


Title:

DIMER OF HUMAN ADENOSINE DEAMINASE ACTING ON DSRNA (ADAR2) MUTANT E488Q BOUND TO DSRNA SEQUENCE DERIVED FROM HUMAN GLI1 GENE

Molecular Description:

Double-stranded RNA-specific editase 1/RNA Complex

Deposited:

2020-01-03

Released:

2020-07-01

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Thuy-Boun, A.S., Thomas, J.M., Grajo, H.L., Palumbo, C.M., Park, S., Nguyen, L.T., Fisher, A.J., Beal, P.A.
Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. 
Nucleic Acids Res., , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 170.0   b = 63.21   c = 142.2 (Ångstroms)

α = 90.0   β = 118.133   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1991 for 32363 reflections in the resolution range 37.48 to 2.8 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)