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NDB ID: 6VG2    PDB ID: 6VG2 


Title:

CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TRANSCRIPTION FACTOR FLI1 IN COMPLEX WITH 16-MER DNA CAGAGGATGTGGCTTC

Molecular Description:

Friend leukemia integration 1 transcription factor/DNA Complex

Deposited:

2020-01-07

Released:

2020-11-25

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hou, C., Mandal, A., Rohr, J., Tsodikov, O.V.
Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. 
Structure, 29, pp. 404 - 412.e4, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 21 21 21

Cell Constants:

a = 79.422   b = 90.732   c = 165.204 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2495 for 5326 reflections in the resolution range 35.0 to 3.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)