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NDB ID: 6VGD    PDB ID: 6VGD 


Title:

CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN (DBD) OF HUMAN FLI1 AND THE COMPLEX OF THE DBD OF HUMAN RUNX2 WITH CORE BINDING FACTOR BETA (CBFB), IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC

Molecular Description:

Friend leukemia integration 1 transcription factor
Runt-related transcription factor 2
Core-binding factor subunit beta/DNA Complex

Deposited:

2020-01-07

Released:

2020-11-25

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Hou, C., Mandal, A., Rohr, J., Tsodikov, O.V.
Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. 
Structure, 29, pp. 404 - 412.e4, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 62 2 2

Cell Constants:

a = 104.513   b = 104.513   c = 322.04 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2947 for 7806 reflections in the resolution range 35.0 to 4.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)