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NDB ID: 6VVS    PDB ID: 6VVS 


Title:

CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH ANTIBIOTIC SORANGICIN

Molecular Description:

DNA-directed RNA polymerase subunit alpha
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
DNA-directed RNA polymerase subunit omega
RNA polymerase sigma factor SigA
unknown
RNA polymerase-binding protein RbpA/DNA Complex

Deposited:

2020-02-18

Released:

2020-10-21

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 7 protein sequences

Primary Citation:

Lilic, M., Chen, J., Boyaci, H., Braffman, N., Hubin, E.A., Darst, S.A., Campbell, E.A.
The antibiotic Sorangicin inhibits DNA unwinding in Rif-resistant mycobacteria
To be published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 132.461   b = 162.908   c = 139.325 (Ångstroms)

α = 90.0   β = 107.32   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2168 for 97815 reflections in the resolution range 54.665 to 3.112 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)