NDB ID: 6W8D    PDB ID: 6W8D     NAKB(beta): 6W8D 

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Title:

STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGT DNA

Molecular Description:

DNA (cytosine-5)-methyltransferase 3A
DNA (cytosine-5)-methyltransferase 3-like/DNA Complex

Deposited:

2020-03-20

Released:

2020-04-15

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Anteneh, H., Fang, J., Song, J.
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. 
Nat Commun, 11, pp. 2294 - 2294, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 205.56   b = 205.56   c = 89.505 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2015 for 43419 reflections in the resolution range 33.159 to 2.598 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)

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Biological Assembly coordinates (pdb format) 1

Structure Factors (cif format)

Coordinates (pdb format, Unix compressed(.gz))

Coordinates (cif format, Unix compressed(.gz))

NMR Restraints (cif format, Unix compressed(.gz))

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