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NDB ID: 6W8J    PDB ID: 6W8J 


Title:

STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CAG DNA

Molecular Description:

DNA (cytosine-5)-methyltransferase 3A
DNA (cytosine-5)-methyltransferase 3-like/DNA Complex

Deposited:

2020-03-20

Released:

2020-04-15

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Anteneh, H., Fang, J., Song, J.
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. 
Nat Commun, 11, pp. 2294 - 2294, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 205.943   b = 205.943   c = 89.371 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1847 for 52247 reflections in the resolution range 43.346 to 2.445 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)