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NDB ID: 6W8V    PDB ID: 6W8V 


Title:

CRYSTAL STRUCTURE OF MOUSE DNMT1 IN COMPLEX WITH ACG DNA

Molecular Description:

DNA (cytosine-5)-methyltransferase 1/DNA Complex

Deposited:

2020-03-21

Released:

2020-07-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Adam, S., Anteneh, H., Hornisch, M., Wagner, V., Lu, J., Radde, N.E., Bashtrykov, P., Song, J., Jeltsch, A.
DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context
Nat Commun, , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.24   b = 152.149   c = 96.049 (Ångstroms)

α = 90.0   β = 94.29   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2471 for 45087 reflections in the resolution range 48.471 to 3.12 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)