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NDB ID: 6WC2    PDB ID: 6WC2 


Title:

CRYSTAL STRUCTURE OF A TERNARY MEF2 CHIMERA/NKX2-5/MYOCARDIN ENHANCER DNA COMPLEX

Molecular Description:

MEF2 Chimera
Homeobox protein Nkx-2.5/DNA Complex

Deposited:

2020-03-29

Released:

2020-07-22

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Lei, X., Zhao, J., Sagendorf, J., Rajashekar, N., Xu, J., Machado, A.C.D., Sen, C., Rohs, R., Feng, P., Chen, L.
Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. 
J.Mol.Biol., , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 69.37   b = 133.9   c = 140.04 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.1876 for 72858 reflections in the resolution range 70.12 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)