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NDB ID: 6WPH    PDB ID: 6WPH 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH DSDNA AND (-)-FTC

Molecular Description:

Reverse transcriptase/ribonuclease H
p51 RT/DNA Complex

Deposited:

2020-04-27

Released:

2020-11-04

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Bertoletti, N., Chan, A.H., Schinazi, R.F., Anderson, K.S.
Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. 
Molecules, 25, pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 165.98   b = 168.054   c = 101.916 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1999 for 37715 reflections in the resolution range 29.52 to 2.72 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)