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NDB ID: 6WQU    PDB ID: 6WQU 


Title:

CSL (RBPJ) BOUND TO NOTCH3 RAM AND DNA

Molecular Description:

Recombining binding protein suppressor of hairless
Neurogenic locus notch homolog protein 3/DNA Complex

Deposited:

2020-04-29

Released:

2021-03-31

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Landor, S.K.J., Santio, N.M., Eccleshall, W.B., Paramonov, V.M., Gagliani, E.K., Hall, D., Jin, S.B., Dahlstrom, K.M., Salminen, T.A., Rivero-Muller, A., Lendahl, U., Kovall, R.A., Koskinen, P.J., Sahlgren, C.
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. 
J.Biol.Chem., , pp. 100593 - 100593, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 66.45   b = 97.66   c = 104.62 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the BUSTER program. The R value is 0.2005 for 26661 reflections in the resolution range 71.39 to 2.41 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)