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NDB ID: 6X1B    PDB ID: 6X1B 


Title:

CRYSTAL STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2 IN THE COMPLEX WITH THE PRODUCT NUCLEOTIDE GPU.

Molecular Description:

Uridylate-specific endoribonuclease/RNA Complex

Deposited:

2020-05-18

Released:

2020-05-27

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kim, Y., Wower, J., Maltseva, N., Chang, C., Jedrzejczak, R., Wilamowski, M., Kang, S., Nicolaescu, V., Randall, G., Michalska, K., Joachimiak, A.
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. 
Commun Biol, 4, pp. 193 - 193, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 63

Cell Constants:

a = 150.875   b = 150.875   c = 111.73 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1649 for 101721 reflections in the resolution range 49.39 to 1.97 Ångstroms with Fobs >  1.41 sigma(Fobs) and with I >  0.0 sigma(I)