A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 14-Oct-2020 number of released structures: 11024
Search for released structures

NDB ID: 6XH1    PDB ID: 6XH1 


Title:

CO-CRYSTAL STRUCTURE OF HIV-1 TAR RNA IN COMPLEX WITH LAB-EVOLVED RRM TBP6.7 MUTANT

Molecular Description:

TAR binding protein mutant 6.7 Q48R/T50R/RNA Complex

Deposited:

2020-06-18

Released:

2020-10-14

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chavali, S.S., Mali, S.M., Jenkins, J.L., Fasan, R., Wedekind, J.E.
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 40.226   b = 40.226   c = 293.949 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2185 for 7660 reflections in the resolution range 39.85 to 2.601 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)