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NDB ID: 6XH3    PDB ID: 6XH3 


Title:

CO-CRYSTAL STRUCTURE OF HIV-1 TAR RNA IN COMPLEX WITH LAB-EVOLVED RRM TBP6.3

Molecular Description:

TAR BINDING PROTEIN TBP 6.3/RNA Complex

Deposited:

2020-06-18

Released:

2020-10-14

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chavali, S.S., Mali, S.M., Jenkins, J.L., Fasan, R., Wedekind, J.E.
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 40.602   b = 40.602   c = 291.98 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2158 for 11000 reflections in the resolution range 39.117 to 2.353 Ångstroms with Fobs >  1.4 sigma(Fobs) and with I >  0.0 sigma(I)