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NDB ID: 6XHY    PDB ID: 6XHY 


Title:

CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH TELITHROMYCIN, MRNA, AMINOACYLATED A- AND P-SITE TRNAS, AND DEACYLATED E-SITE TRNA AT 2.60A RESOLUTION

Molecular Description:

ribosome

Deposited:

2020-06-19

Released:

2020-12-23

Nucleic Acid Sequence:

Click to show/hide 7 nucleic acid sequences

Protein Sequence:

Click to show/hide 49 protein sequences

Primary Citation:

Svetlov, M.S., Syroegin, E.A., Aleksandrova, E.V., Atkinson, G.C., Gregory, S.T., Mankin, A.S., Polikanov, Y.S.
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. 
Nat.Chem.Biol., 17, pp. 412 - 420, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 209.4   b = 448.12   c = 618.73 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2193 for 1730293 reflections in the resolution range 224.06 to 2.6 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)