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NDB ID: 6XKI    PDB ID: 6XKI 


Title:

CRYSTAL STRUCTURE OF EIF4A-I IN COMPLEX WITH RNA BOUND TO DES-MEPATEA, A PATEAMINE A ANALOG

Molecular Description:

Eukaryotic initiation factor 4A-I/RNA Complex

Deposited:

2020-06-26

Released:

2021-01-06

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Naineni, S.K., Liang, J., Hull, K., Cencic, R., Zhu, M., Northcote, P., Teesdale-Spittle, P., Romo, D., Nagar, B., Pelletier, J.
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. 
Cell Chem Biol, , pp. - , 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 66.785   b = 99.942   c = 153.663 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2238 for 10624 reflections in the resolution range 45.58 to 2.87 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)