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NDB ID: 6XLX    PDB ID: 6XLX 


Title:

CRYSTAL STRUCTURE OF CANCER-ASSOCIATED G301D MUTANT OF U2AF65 BOUND TO ADML SPLICE SITE

Molecular Description:

Splicing factor U2AF 65 kDa subunit/RNA Complex

Deposited:

2020-06-29

Released:

2020-10-07

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Maji, D., Glasser, E., Henderson, S., Galardi, J., Pulvino, M.J., Jenkins, J.L., Kielkopf, C.L.
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. 
J.Biol.Chem., 295, pp. 17148 - 17157, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 43.492   b = 61.875   c = 77.421 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1649 for 44173 reflections in the resolution range 38.71 to 1.7 Ångstroms with Fobs >  1.91 sigma(Fobs) and with I >  0.0 sigma(I)