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NDB ID: 6XQD    PDB ID: 6XQD 


Title:

CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH SARECYCLINE, UUC-MRNA, AND DEACYLATED P-SITE TRNA AT 2.80A RESOLUTION

Molecular Description:

ribosome

Deposited:

2020-07-09

Released:

2020-08-05

Nucleic Acid Sequence:

Click to show/hide 5 nucleic acid sequences

Protein Sequence:

Click to show/hide 49 protein sequences

Primary Citation:

Batool, Z., Lomakin, I.B., Polikanov, Y.S., Bunick, C.G.
Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. 
Proc.Natl.Acad.Sci.USA, 117, pp. 20530 - 20537, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 208.33   b = 447.6   c = 612.33 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2272 for 1363663 reflections in the resolution range 75.46 to 2.8 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)