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NDB ID: 6YCS    PDB ID: 6YCS 


Title:

HUMAN TRANSCRIPTION COFACTOR PC4 DNA-BINDING DOMAIN IN COMPLEX WITH FULL PHOSPHOROTHIOATE 5-10-5 2'-O-METHYL DNA GAPMER ANTISENSE OLIGONUCLEOTIDE.

Molecular Description:

PC4 protein/DNA Complex

Deposited:

2020-03-19

Released:

2020-04-29

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hyjek-Skladanowska, M., Vickers, T.A., Napiorkowska, A., Anderson, B.A., Tanowitz, M., Crooke, S.T., Liang, X.H., Seth, P.P., Nowotny, M.
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins. 
J.Am.Chem.Soc., 142, pp. 7456 - 7468, 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 102.143   b = 102.143   c = 83.813 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2415 for 8886 reflections in the resolution range 45.68 to 3.05 Ångstroms with Fobs >  1.37 sigma(Fobs) and with I >  0.0 sigma(I)